Electrostatic and Covalent Binding of an Antibacterial Polymer to Hydroxyapatite for Protection against Escherichia coli Colonization

Orthopedic-device-related infections are notorious for causing physical and psychological trauma to patients suffering from them. Traditional methods of treating these have relied heavily on antibiotics becoming ineffectual due the rise antibiotic-resistant bacteria. Mimics antimicrobial peptides emerged as exciting alternatives their favorable antibacterial properties lack propensity generating resistant In this study, efficacy an polymer a coating material hydroxyapatite glass surfaces, two materials with wide ranging application in orthopedics biomedical sciences, is demonstrated. Both covalent modes attachment were explored. Polymer surfaces was confirmed via X-ray photoelectron spectroscopy contact angle measurements. The modified exhibited significant activity against Gram-negative bacterium E. coli, retained prolonged period covalently materials.